The Metabolism of L-Arginine and Its Importance in Immune Function

Authors

  • Ben Su
  • Patrick Rudak
  • Charles Yin

DOI:

https://doi.org/10.15173/m.v1i26.947

Abstract

The importance of arginine in maintaining the homeostasis of the
immune system is a focus of the emerging field of immunometabolism,
and is representative of the growing body of knowledge on the role of
metabolites in immune function. Arginine plays a critical role in the function
of the immune system, as arginine deficiency in macrophages leads to a
defect in nitric oxide production. Consequently, this results in decreased
macrophage elimination of pathogens. Additionally, myeloid suppressor
cells (MSCs) have been shown to exert regulatory effects on activated
T-cells by utilizing arginine metabolism in various different pathways.
Decreased levels of arginine have also been observed to interfere with
proper B-cell maturation and IgM production, all of which ultimately impair
the adaptive immune response. In this review, the importance of arginine
in the context of immune system is explored.

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Published

2014-12-21

How to Cite

1.
Su B, Rudak P, Yin C. The Metabolism of L-Arginine and Its Importance in Immune Function. M [Internet]. 2014 Dec. 21 [cited 2024 Mar. 28];1(26). Available from: https://journals.mcmaster.ca/meducator/article/view/947

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Section

Critical Reviews

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