A mixed-methods systematized review on the efficacy of OAT in mitigating adverse outcomes amongst adults in Canada experiencing opioid dependence from 1964-2022
This systematized review was guided by the PICOT question: For persons experiencing opioid dependence in Canada from 1964-2022, is the administration of OAT associated with a reduced risk of adverse quantitative and qualitative outcomes? Results demonstrated improved self-reported well-being and reduced opioid use, overdose, mortality, hospitalizations, incarceration, and economic costs. Retention was identified as a limiting factor for OAT efficacy with numerous variables impacting retention. Results can be extended to the global health context given Canada’s predictive value as the second leading country in terms of opioid use. This is an abridged version of the full systematized review, which is available upon request.