Challenges in Conducting International Clinical Research in Low- and Middle-income Countries

Abstract

The most impactful research comes from the international collaboration of researchers from interdisciplinary backgrounds. The involvement of different countries, cultures, and perspectives is needed to combat the increasingly complex healthcare issues arising today. Although it is well accepted that this collaboration is key to meaningful research, many developing countries are often underrepresented within the literature. Research from low-middle income countries is needed, but there are many challenges that come with their inclusion. These differ between country and type of trial but are generally categorized into technological, cultural and geographical, financial, political and economic, human resource and infrastructure, and operational barriers. Further exploration into these challenges, specific areas of need, and potential improvements are necessary for the future of clinical research and health outcomes of the global population.